Lionel Messi will miss Paris Saint Germain’s visit to Metz in Ligue 1 on Wednesday due to a left knee injury.
Messi, who was substituted on his home debut against Lyon on Sunday, underwent an MRI which confirmed signs of bruising to his bones.
French league officials confirmed on Tuesday that the striker will undergo a follow-up examination in 48 hours.
Messi, 34, has failed to score in his first three appearances since joining a free transfer in August after leaving Barcelona.
Mauricio Pochettino’s side are due to play against Montpellier at home in the league on Saturday before hosting Manchester City in the Champions League on Tuesday.
Messi, who hit the crossbar with a free kick in the first half against Lyon, appeared frustrated at being replaced by Achraf Hakimi in the 76th minute of the 2-1 return win this weekend.
However, speaking in his pre-match press conference, Pochettino said: “I’m really happy with what he did during the game, he played a great first half.
“Not all great champions want to leave the field.”